This essay confronts Ray Brassier’s vindication of nihilism with other two important but frequently underexamined philosophical attempts to overcome nihilism: Hans Jonas’ and Keiji Nishitani’s. By putting these different takes on nihilism into dialogue, it explores some blind spots in Brassier’s position, as well as some of the practical consequences, for our current planetary situation, of undertaking a radical divorce between the normative and the natural that results from his radical nihilism. The article opts for a more moderate acceptance and (...) eventual self-overcoming of nihilism, according to which, even if natural entities are indifferent to human reasons and meanings, this does not entail that nature is bereft of a human-independent normative dimension. In other words, the essay argues that care must be taken not to confuse criticisms of an anthropocentric conception of reasons and meanings with the belief that meaning is completely absent from the natural world. Thus, the central contention of the article is that, given our current climate and ecological catastrophe, one of the most pressing tasks of contemporary philosophy is to understand normativity in non-anthropocentric ways, so that humans are no longer considered as the only entities that respond to normativity. Such an attitude conceives humans as estranged normative creatures amidst a meaningless, indifferent natural world, toward which they would have no ethical responsibilities. The essay finishes by suggesting ways in which to develop an account that does not fall into this ethical vacuum. (shrink)

Many diseases and disease symptoms still lack effective treatment. At the same time, certain controversial Schedule I drugs, such as heroin and cannabis, have been reputed to have considerable therapeutic potential for addressing significant medical problems. Yet, there is a paucity of U.S. clinical studies on the therapeutic uses of controlled drugs. For example, people living with HIV/aids experience a variety of disease- and medication-related symptoms. Their chronic pain is intense, frequent, and difficult to treat. Nevertheless, clinical trials of compassionate (...) management for their chronic symptoms, which should be a research priority, are stymied. Stakeholders’ Views on Barriers to Research on Controlled Substances Evelyn Rhodes, Michael Andreae, Tyler Bourgiose, Debbie Indyk, Rosamond Rhodes, and Henry Sacks We employed qualitative methods to develop an understanding of the barriers to research on potential therapeutic uses of Schedule I drugs so that they might be addressed. We elicited the perspectives of key stakeholder groups that would be involved in such studies: people living with HIV/aids, clinicians, and members of institutional review boards. As we identified obstacles to research, we found that all of the stakeholder groups arrived at the same conclusion, that clinical research on the therapeutic potential of these drugs is ethically required. (shrink)

Evaluating the Knowledge and Practice of Limitation of Therapeutic Effort in Health Workers at a Health Care Institution for Cancer Patients in Medellín, 2018Avaliação do conhecimento e da prática da limitação de esforço terapêutico em equipe de atendimento de uma instituição prestadora de serviços de saúde para pacientes oncológicos de Medellín, 2018Limitation of therapeutic effort is any action that involves suspending or not initiating medical treatment or therapeutic measures in patients who will not receive any clinical benefit. In Latin America, (...) some research has proven a lack of familiarization and disagreement with the subject and its practices. The present study tried to objectify the knowledge of LTE of healthcare personnel at an institute in Medellín using a self-administered survey that allowed conducting a cross-sectional descriptive study with non-probabilistic sampling. Within the results, 56.5 % of respondents understood the concept of LTE, and 90 % applied it actively. However, there were discrepancies regarding the core concepts of the definition and practice.Para citar este artículo / To reference this article / Para citar este artigoVallejo LI, Palacio AM, Marulanda V, Restrepo A, Yepes LA, Valencia NL, Cruz MA. Evaluación del conocimiento y práctica de la limitación del esfuerzo terapéutico en personal asistencial de una institución prestadora de servicios de salud para pacientes oncológicos de Medellín, 2018. 2020;24:177-87. DOI: https://doi.org/10.5294/pebi.2020.24.2.5Recibido: 19/07/2019Aceptado: 08/08/2020Publicado: 27/11/2020. (shrink)

In their paper, “Helpful Lessons and Cautionary Tales: How Should COVID-19 Drug Development and Access Inform Approaches to Non-Pandemic Diseases?” Holly Fernandez Lynch and colleagues have present...

We examine the ethical, social, and regulatory barriers that may hinder research on therapeutic potential of certain controversial controlled substances like marijuana, heroin, or ketamine. Hazards for individuals and society and potential adverse effects on communities may be good reasons for limiting access and justify careful monitoring of these substances. Overly strict regulations, fear of legal consequences, stigma associated with abuse and populations using illicit drugs, and lack of funding may, however, limit research on their considerable therapeutic potential. We review (...) the surprisingly sparse literature and address the particular ethical concerns pertinent to research with illicit and addictive substances, such as undue inducement, informed consent, therapeutic misconception, and risk to participants, researchers, and institutions. We consider the perspectives of key research stakeholders and explore whether they may be infected with bias. We conclude by proposing an empirical research agenda to provide an evidentiary basis for ethical reasoning. (shrink)

Perseitas vol. 9 de 2021 contiene una selección de 2 artículos de investigación científica y tecnológica, 17 artículos de reflexión derivados de investigación, 4 artículos de reflexión no derivado de investigación, 1 muestra de poemas y 1 entrevista. Como es usual, esta entrega se caracteriza por ofrecer un amplio abanico de temas dentro del área de las humanidades.

As a contribution to the emerging field of corporate social responsibility cognition, this article reports on the findings of an exploratory study that compares SME owner–managers’ mental models with regard to CSR and related concepts across six European countries. Utilising Repertory Grid Technique, we found that the SME owner–managers’ mental models show a few commonalities as well as a number of differences across the different country samples. We interpret those differences by linking individual cognition to macro-environmental variables, such as language, (...) national traditions and dissemination mechanisms. The results of our exploratory study show that nationality matters but that classifications of countries as found in the comparative capitalism literature do not exactly mirror national differences in CSR cognition and that these classifications need further differentiation. The findings from our study raise questions on the universality of cognition of academic management concepts and warn that promotion of responsible business practice should not rely on the use of unmediated US American management terminology. (shrink)

Morin envisions the adaptive landscape of graphic codes as an unfertile valley where writing rises as an isolated peak that humans managed to reach only on four occasions throughout all of history. By exploring the different paths to cultural convergence, we suggest an alternative landscape occupied by a mountain range of visual art systems. We conclude that graphic communication through visual art worked well enough to render writing contingent but not necessary in most cases.

The vast majority of empirical research on stakeholder management has traditionally focused on multinational corporations. Only in recent years, scholars have begun to pay attention to the stakeholder management concept in relation to small- and medium-sized enterprises (SMEs). The few existing studies in this area, however, discuss SMEs as a context free category or remain focused on single country analysis. This cross-national empirical research investigates SME owner–managers’ perceptions of stakeholder management in six European countries. The comparative analysis is followed by (...) a discussion of how institutional, cultural and linguistic contexts can influence owner–managers’ sensemaking of stakeholder management. Our study questions the universality of specific management terms and proposes that more attention should be paid to the institutional, cultural and linguistic environments that shape economic activity in different parts of Europe. (shrink)

The vast majority of empirical research on stakeholder management has traditionally focused on multinational corporations. Only in recent years, scholars have begun to pay attention to the stakeholder management concept in relation to small- and medium-sized enterprises (SMEs). The few existing studies in this area, however, discuss SMEs as a context free category or remain focused on single country analysis. This cross-national empirical research investigates SME owner-managers' perceptions of stakeholder management in six European countries. The comparative analysis is followed by (...) a discussion of how institutional, cultural and linguistic contexts can influence owner-managers' sensemaking of stakeholder management. Our study questions the universality of specific management terms and proposes that more attention should be paid to the institutional, cultural and linguistic environments that shape economic activity in different parts of Europe. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Este artículo traza una relación entre tres de los autores más influyentes de la doctrina del atomismo lógico a partir de la noción de análisis lógico, sin embargo, dicha relación busca no solo la constatación de su cercanía doctrinal sino la concepción ontológica que subyace a la posibilidad de dicho análisis, para el caso de Russell y Wittgenstein, o su ausencia, para el caso de Carnap, lo cual, no obstante, no aleja a este de preocupaciones de carácter metafísico, ya que (...) en los tres autores la relación entre lenguaje y mundo, ya sea desde la dimensión ontológica o epistemológica, comporta una reflexión de primer orden. Para exponer lo anterior se recurre a dilucidar la relación entre nombres propios y hechos (Russell), objetos simples y estado de cosas (Wittgenstein) y la postura de la Ciencia Unificada (Carnap) con respecto a la representación de hechos o cosas. (shrink)

As a contribution to the emerging field of corporate social responsibility cognition, this article reports on the findings of an exploratory study that compares SME owner–managers’ mental models with regard to CSR and related concepts across six European countries. Utilising Repertory Grid Technique, we found that the SME owner–managers’ mental models show a few commonalities as well as a number of differences across the different country samples. We interpret those differences by linking individual cognition to macro-environmental variables, such as language, (...) national traditions and dissemination mechanisms. The results of our exploratory study show that nationality matters but that classifications of countries as found in the comparative capitalism literature do not exactly mirror national differences in CSR cognition and that these classifications need further differentiation. The findings from our study raise questions on the universality of cognition of academic management concepts and warn that promotion of responsible business practice should not rely on the use of unmediated US American management terminology. (shrink)

Dans cet ouvrage, A. Falcon propose une histoire de l’aristotélisme qui examine la présence et la fortune de la pensée d’Aristote dans le monde antique. L’originalité du livre ne réside pas dans son objet, comme le souligne l’auteur en mentionnant dès l’introduction le travail colossal publié en 1973 par Paul Moraux sur l’aristotélisme, d’Andronicos de Rhodes à Alexandre d’Aphrodise (Der Aristotelismus bei den Griechen, von Andronikos bis Alexander von Aphrodisias, Berlin, 1973). Elle réside...

The concept of the republic is a complex meta-principle that facilitates and conceals global relations of domination. Specifically, it enables the invisibility of racism as the core of political power. From its very origins the concept of republic serves to seize constituent power or politeia. In modernity, as it merges with private property, it will serve as the launchpad of a vast colonization project that then evolves in a new form of power in coloniality. The article applies the theory of (...) the ‘encryption of power’—to decrypt the historical concept of the republic. In doing so, we will demonstrate the key antidemocratic role it has played at the heart of global coloniality. We will bear witness as to how, from within the concept of republic, a refined mechanism of domination raises and expands, conforming the most magnificent and lethal form of power of our times. We exemplify our theory showing that the concept of ‘republic’ is the common thread between the law that abolished slavery in Brazil (known as Lei Aurea) and the 1988 constitution. Within this scope, we propose a vital space of reconsideration of political ontology through radical democracy as the only means to build the world from immanent difference. (shrink)

Im Mittelpunkt der vorliegenden Studie steht die Frage nach der Tragweite und Anwendungsrelevanz der Methodenlehre Émilie du Châtelets für die Physik im 18. Jahrhundert, mit der sich die Französin an der Diskussion um Energie- und Impulserhaltung und um das Prinzip der kleinsten Wirkung beteiligte. Andrea Reichenberger zeigt, dass Prinzipien und Hypothesen für Émilie du Châtelet als Fundament und Gerüst wissenschaftlicher Erkenntnis gelten. Im Zusammenspiel beider Komponenten erweisen sich das Prinzip des Widerspruchs und das Prinzip des zureichenden Grundes als regulative (...) Leitlinien und Handlungsmaxime für die auf Hypothesen gestützte Theoriebildung und -begründung. Die sich daraus ergebenden Konsequenzen für den Status und Inhalt der Newtonschen Axiome werden exemplarisch aufgezeigt. (shrink)

Several attempts have been made previously to provide a biological grounding for cognitive architectures by relating their components to the computations of specific brain circuits. Often, the architecture's action selection system is identified with the basal ganglia. However, this identification overlooks one of the most important features of the basal ganglia—the existence of a direct and an indirect pathway that compete against each other. This characteristic has important consequences in decision-making tasks, which are brought to light by Parkinson's disease as (...) well as genetic differences in dopamine receptors. This paper shows that a standard model of action selection in a cognitive architecture cannot replicate any of these findings, details an alternative solution that reconciles action selection in the architecture with the physiology of the basal ganglia, and extends the domain of application of cognitive architectures. The implication of this solution for other architectures and existing models are discussed. (shrink)

On a dreary spring morning in late October 2006, two policemen drove their cruiser up Nkonjane Road in the K Section of KwaMashu, a former “Africans only” township about fifteen kilometers northwest of Durban. As the cruiser passed over K Section’s softly sloping hills, two men sat handcuffed together in the back. The officers parked the car in front of a house where a woman had reported being raped a few days prior. Leaving the two suspects in the car, the (...) officers alighted and walked up to the home. After greeting the victim, they asked her to step outside to identify the men. The victim, upon seeing the two men seated in the squad car, loudly screamed that they were the rapists... The crowd... (shrink)

Currently much debate surrounds the significance of cross-cultural variation in mother-infant attachment. Is only one form of attachment “healthy,” or are different types of attachment adaptations to local socioecological conditions? Juvenile mortality rates have been promoted as important features of local environments that shape attachment, which in turn affects later reproductive strategies. To this we add fertility. Fertility changes the environment of a child by influencing the number of potential caregivers and competitors for care, and the cultural ethos regarding the (...) rights of children. Different combinations of fertility and mortality will likely give rise to different attachment forms, and only under one regime (low fertility and mortality) do we expect exclusivity in attachment. (shrink)

Ontologies are created to describe and reason over the knowledge of a domain of interest. This requires deep understanding of the domain, and therefore, the input and collaboration of the domain’s...

RESUMEN Un atento repaso por la concepción de la violencia chulhaniana en el contexto de las formas tradicionales que han estudiado este fenómeno social permite exponer con mayor detalle y claridad esta propuesta en cuanto a la relación con el otro se refiere. Cuando lo sucedido durante el colonialismo que azotó al mundo en el transcurso de los siglos XVIII y XIX se asumía como las más peligrosas acciones cometidas en procura de la supresión de las características propias de cada (...) uno, en la medida en que los fenómenos de invasión suprimían materialmente la diferencia que poblaba el mundo, apareció la violencia de la positividad como la disposición sistémica que parte de la libertad y el consentimiento individual para, tácitamente, eliminar cualquier tipo de sentido de otredad presente en su constitución. ABSTRACT A careful review of the conception of Chulhanian violence in the context of the traditional forms that have studied this social phenomenon makes it possible to explain in greater detail and clarity this proposal as to the relationship with the other refers. When what happened during colonialism that hit the world during the 18th and 19th centuries was assumed to be the most dangerous actions committed in seeking the suppression of each other's own characteristics to the extent that invasion phenomena materially suppressed the difference that populated the world, the violence of positivity appeared as the systemic disposition that begins with freedom and individual consent to, tacitly, to eliminate any kind of sense of otherness present in its constitution. (shrink)

What to do with Adorno’s Aesthetic Theory? An Interview with Jacques Rancière Conducted by Andrea Allerkamp, Katia Genel, and Mariem Hazoume Translated by Owen Glyn-Williams This interview was originally published in French as “Que faire de la théorie esthétique d’Adorno?” in Où en sommes-nous avec la Théorie esthétique d'Adorno?.